• br Conclusions Several lines of evidence have been establish

  2024-04-02

  

  Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute Okadaic acid injury to initial downregulation of ADK, rise in extracellular adenosine, changes in astrocytic ad

• br Patients and methods The

  2024-04-02

  

  Patients and methods The severity of disease documented at each outpatient visit was graded according to the modified Osserman classification: grade I, focal disease (e.g. restricted to ocular muscles); grade II, generalised disease that is mild (IIa) or moderate (IIb); grade III, severe generali

• Comparatively cell based assays appear to be the most sensit

  2024-04-02

  

  Comparatively, cell-based assays appear to be the most sensitive method to detect patient autoantibodies directed at neurotransmitter receptors. Leite et al. demonstrated that many α-BTX RIA seronegative myasthenic patients do have autoantibodies against the AChR when a highly sensitive immunofluore

• br Disclosure br Acknowledgement br Introduction

  2024-04-02

  

  Disclosure Acknowledgement Introduction CYP17A1 is a multifunctional enzyme with both 17α-hydroxylase and 17,20-lyase activities and is essential for the biosynthesis of steroidal Meleagrin synthesis in male testes and adrenal glands. The 17α-hydroxylase activity of CYP17A1 is involved in

• Acknowledgments br Introduction Prostate cancer

  2024-04-02

  

  Acknowledgments Introduction Prostate cancer is the first leading cause of cancer-related deaths among males in the UK and the second in the US. Despite recent advances in surgery, radiation, medical management and screening, prostate cancer patients suffer high morbidity and mortality and signi

• Despite their different effects on cell survival the functio

  2024-04-02

  

  Despite their different effects on cell survival, the functions of autophagy and apoptosis are not completely independent. Additionally, Cho et al. (2009) suggested that the mediation of caspase-3 links the apoptotic and autophagic signaling pathways. Consequently, to illuminate the correlation, exc

• br Materials and methods br Results br

  2024-04-02

  

  Materials and methods Results Discussion Fluoride can readily penetrate cellular membranes and seriously damage the structure and physiological function of cells (Zhou et al., 2015). Several studies have shown that excessive fluoride can decrease the viability of cells and that the growth o

• Phenolic compounds show reciprocal relationship with colonic

  2024-04-02

  

  Phenolic compounds show reciprocal relationship with colonic microflora. Phenolic compounds are able to improve colonic health and modulate microbiota diversity with prebiotic and antimicrobial functions, while colonic bacterial enzymes catalyze deconjugation, dehydroxylation, and convert phenolic c

• br Results br Discussion Using primarily an electrophysiolog

  2024-04-01

  

  Results Discussion Using primarily an electrophysiological analysis of dysbindin-deficient hippocampal neurons in cultures and slices, we have uncovered a previously unreported role for dysbindin in enhancing CA3–CA1 AMPAR-mediated transmission. An earlier study, however, has reported a reduct

• The control group participants of the current study were ver

  2024-04-01

  

  The control group participants of the current study were very similar in age to those of Puertas et al. There was no significant correlation between age and enzyme activity over the short age span studied although age-related changes in the activity of ApA and aspartyl aminopeptidase, typically incr

• br Animal models of NAFLD

  2024-04-01

  

  Animal models of NAFLD Human research has greatly shaped our understanding of non-alcoholic fatty liver disease, but several limitations exist in studying the disease processes in humans, such as variations in environmental exposure, pre-existing genetic risk factors, racial and ethnic difference

• We have previously shown that the human gonadotropins

  2024-04-01

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor Exendin-3 (9-39) amide (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a bette

• To assess relative metabolic activity and proliferation

  2024-04-01

  

  To assess relative metabolic activity and proliferation of QX 314 chloride attached to various substrates we used the MTT assay [29], [30]. In order to compare the metabolic activity of cells under the various conditions irrespective of the number or viability of the cells, we performed a PicoGreen

• The difference in the mean values of serum ADA in

  2024-04-01

  

  The difference in the mean values of serum ADA in sputum positive PTB and controls was found to be highly significant (P Discussion Tuberculosis is a major health problem in India, and out of all its forms PTB is the commonest. A definite diagnosis of PTB can be made with the presence of p-nitro-C

• Another significant group of reductase inhibitors is

  2024-04-01

  

  Another significant group of 5α-reductase inhibitors is the steroidal 3-carboxylic 2665 derivatives (relevant examples in Fig. 5), which were designed to mimic the putative enzyme-bound enolate intermediate. This was achieved by introducing sp2-hybridized centers at C3 and C4 and an anionic carboxyl

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